anastrozole will raise the level or impact of tadalafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Mysterious.Sildenafil is cleared predominantly via the CYP3A4 (main route) and CYP2C9 (minimal route) hepatic microsomal isoenzymes. The foremost circulating metabolite outcomes from N-demethylation of sildenafil. T